DEFINING NEW THERAPEUTICS USING A MORE IMMUNOCOMPETENT MOUSE MODEL OF ANTIBODY-ENHANCED DENGUE VIRUS INFECTION

Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection

ABSTRACT With over 3.5 billion people at risk and approximately 390 million human infections per year, dengue virus (DENV) disease strains health care resources worldwide.Previously, we and others established models for DENV pathogenesis in mice that completely lack subunits of Fryer the receptors (Ifnar and Ifngr) for type I and type II interferon

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The orbital and sinonasal hemangiopericytoma, 2 case reports:

Background & objective: Hemangiopericytoma is an uncommon vascular tumor derived from the pericytes of Zimmermann.The most common location of the tumor is pelvic retroperitoneum and musculoskeletal system of the lower extremities.It is rarely seen in the head and neck area.In Bracelet Gift Box addition, only 0.8% to 3% of all orbital tumo

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Non-oncogenic Acute Viral Infections Disrupt Anti-cancer Responses and Lead to Accelerated Cancer-Specific Host Death

In light of increased cancer prevalence and cancer-specific deaths in patients with infections, we investigated whether infections alter anti-tumor immune responses.We report that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death.Furthermore, we show that during i

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