Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection
ABSTRACT With over 3.5 billion people at risk and approximately 390 million human infections per year, dengue virus (DENV) disease strains health care resources worldwide.Previously, we and others established models for DENV pathogenesis in mice that completely lack subunits of Fryer the receptors (Ifnar and Ifngr) for type I and type II interferon